Activation of EGFR/MEK signaling in the primary tumor has been recently linked to MEK activation and wasting in host tissues [102], and while CAFs as a source for these ligands or for PTHrP have not been specifically addressed, EGFR signaling has been functionally linked to cachexia and/or energy expenditure in additional systems [103,104]. This evidence concerns the gene MAP2K7 and neoplasm.