Among these miRNAs, we found that five miRNAs (miR-130b-3p, miR-196a-3p, miR-301a-3p, miR-421 and miR-454-3p) possessed the greatest potential in targeting PIEZO2 in breast cancer by combination of correlation analysis, prognosis analysis, expression analysis and text mining. This evidence concerns the gene PIEZO2 and breast cancer.