Of particular note is that, while normally associated with forms of dementia such as Alzheimer's disease, tau protein accumulation is commonly observed in examinations of post mortem brain tissue from individuals who were clinically healthy at death (Davis, Schmitt, Wekstein, & Markesbery, 1999; Knopman et al., 2003). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.