Tumor burden factors are usually defined as tumor size, lymph node invasion, and lymph vascular and dermis invasion, and tumor molecular biological factors usually include tests for hormonal status—including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)—combined with fluorescence in situ hybridization and immunochemistry test results. The gene discussed is ERBB2; the disease is neoplasm.