For example, Wang et al. (133) have demonstrated that the histone H3K27 methyltransferase enhancer of zeste homolog 2 (EZH2) activities are increased in tumor-infiltrating Treg cells in both murine and human cancers, and molecular targeting of EZH2 promoted conversion of Treg cells into IFNγ producing cells that were capable of remodeling the tumor microenvironment and enhancing anti-tumor immunity. Here, EZH2 is linked to neoplasm.