EGFR and non-small cell lung carcinoma: In a randomized, multicenter, open-label, phase III trial (ARCHER 1050), the patients with newly diagnosed advanced NSCLC and one EGFR mutation (exon 19 deletion or L858R) received a 45 mg/day dose of oral dacomitinib or a 250 mg/day gefitinib for 28 days.