In contrast, in systemic infections, such as sepsis, high level of HIF-1α is associated with greater mortality, the increase in the content of proinflammatory cytokines, IL-1β and tumor necrosis factor-α (TNF-α), and the decrease in anti-inflammatory cytokine IL-10, which promotes the development of proinflammatory reactions [22]. This evidence concerns the gene HIF1A and Sepsis.