SOX9 and malignant colon neoplasm: All this data indicated that SOX9, β-catenin, and PPARγ expression levels were deregulated in the CRC tissue, and in colon cancer cell lines ligand-dependent PPARγ activation unevenly influences SOX9 and β-catenin expression and subcellular localization, suggesting a variable mechanistic role in colon carcinogenesis [52].