Nevertheless, in the particular case of DLD-1 CRC cell line, which has a heterozygous L142P inactivating mutation of SOX9, the restoration of wild type SOX9 expression results in an oncoprotective activity which inhibits cell growth, clonal capacity, and colonosphere formation while decreasing both the activity of the oncogenic Wnt/ß-catenin signaling pathway and the expression of the c-MYC oncogene [6]. Here, SOX9 is linked to colorectal carcinoma.