As previously mentioned, various genetic alterations are present in subgroups of tumors with different clinical characteristics and outcomes; of relevance, mutations in the CTNNB1 gene encoding for β-catenin and in the TP53 gene encoding for the tumor suppressor p53 proteins have been defined as poor prognostic factors for ACC [19]. The gene discussed is CTNNB1; the disease is adrenal cortex carcinoma.