It is reported that numerous human genetic diseases were caused by single nucleotide mutation, such as the 878 G > A (AVPR2 W293X) in X-linked Nephrogenic diabetes insipidus and the 1517 G > A (FANCC W506X) in Fanconi anemia (Cox et al., 2017). This evidence concerns the gene AVPR2 and nephrogenic diabetes insipidus.