In CD8+ T cells, miRNAs (miR-23b, miR-98, and miR-590-5p) can reduce the expression of several key apoptotic molecules, such as FAS, FASLG, TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL-R2, indicating they can serve as modifiers of disease susceptibility in T1D patients (153). The gene discussed is CD8A; the disease is type 1 diabetes mellitus.