For example, oxidative stress induced the expression of serine/threonine-protein phosphatase 2A catalytic subunit α (PP2ACA) isoform through reducing activity of DNMT1 and ultimately leading to demethylation of the promoter of PPP2CA to contribute to the pathology of SLE (167, 168) (Figure 5). This evidence concerns the gene DNMT1 and systemic lupus erythematosus.