CD8A and neoplasm: Moreover, ACY241, another HDAC inhibitor, activates the AKT/mTOR/p65 pathways and upregulates transcription regulators including Bcl-6, Eomes, HIF-1 and T-bet, which result in increased proliferation and cytolytic function of antigen-specific CD8+ TEM cells with stronger anti-tumor activities in multiple myeloma and solid tumors (101).