Previous studies have indicated a key role for the IFN-γ receptor (IFN-γR) in development of autoantibody production in lupus-prone mice, e.g., MRL/Lpr, NZB/W, B6.Sle1b, and Roquin san/san (15–18). The gene discussed is IFNGR1; the disease is systemic lupus erythematosus.