STAT3 pharmacological inhibition (by peptidomimetics, small molecule inhibitors, platinum agents, curcumin, JAK inhibitors, AG490, Cucurbitacin B) simultaneously blocks angiogenesis and accumulation/suppressive function of MDSC, neutralizing the induction of a tolerogenic/tumor permissive TME, without MDSC depletion (158, 200–202). This evidence concerns the gene STAT3 and neoplasm.