TNFSF10 and common variable immunodeficiency: In this study we also identified a heterozygous missense variant in TNFSF10 (TRAIL) in all the affected individuals of Family A. Mutations in TNFSF10 have not been reported to be associated with a CVID-like phenotype, however, due to the role of TRAIL in regulating B cells responses (59, 60), mutation in this gene were considered as a candidate to modify the CVID phenotype.