Thus, the IKZF1 mutation p.Arg143Trp, identified in Family A was shown to impair the function of IKAROS, though it can also be possible that the CVID-like phenotype in this family can be the results of the contribution of IKZF1 mutation and the missense variant identified in TNFSF10. The gene discussed is TNFSF10; the disease is common variable immunodeficiency.