Anti-CCP antibodies were positively correlated with total IgA anti-ghrelin autoantibodies (r = 0.326, p = 0.022) and the DAS-28 activity score showed a positive correlation with free IgA anti-ghrelin autoantibodies (r = 0.296, p = 0.050).When addressing the relationship between metabolic profile in RA with free and total fractions of anti-ghrelin, we detected a negative correlation between visceral fat level and total IgG anti-ghrelin autoantibodies (r = −0.519, p = 0.000). This evidence concerns the gene CD79A and rheumatoid arthritis.