This has been the case for a secreted protein named homologous to Lymphotoxin, exhibits Inducible expression and competes with HSV Glycoprotein D for binding to Herpesvirus entry mediator, a receptor expressed on T lymphocytes (LIGHT, a.k.a. Tumor Necrosis Factor SuperFamily member 14, TNFSF14), which has been linked to increased bone resorption in osteoarthritis more than 10 years ago (146, 147), and has known a renaissance in the last few years as target for bone loss (148) and biomarker for bone disease in multiple myeloma (149). This evidence concerns the gene TNFSF14 and osteoarthritis.