IL2 and neoplasm: To improve the anti-tumor effect of NK cells for ovarian tumors through enhancing the numbers of NK cells into tumors and to prolong viability of NK cells without administration of exogenous IL-2, in this study, we investigated whether UTMD can assist adoptive NK-92MI cells to accumulate into ovarian tumors from blood vessels, and further explored the treatment effects of the combination of UTMD and NK-92MI cells in ovarian tumor xenograft.