The memory improvements associated with GLP-1 receptor agonists are not limited to conditions in which amyloid β or hyperphosphorylated tau are present, as GLP-1 receptor agonists are neuroprotective and promote memory retention in senescence accelerated mouse prone 8 (SAMP8) mice, a model of age-related spontaneous AD not associated with amyloid plaques (Hansen et al., 2015). This evidence concerns the gene GLP1R and Alzheimer disease.