GHSR and Anxiety: Moreover, intraperitoneal injection of sertraline, a selective serotonin reuptake inhibitor (SSRI) antidepressant during CSDS procedure, prevent the development of increased anxiety-like behavior (Figure 2D; Ghsr+/+ mice CSDS vs. Sertraline + CSDS, P < 0.01) and despair-like behavior (Figure 2E; Ghsr+/+ mice CSDS vs. Sertraline + CSDS, P < 0.001) induced by CSDS exposure.