In D2R-overexpressing SCZ mice, reduced low-frequency synchrony between dopamine neurons in the ventral tegmental area and prefrontal cortex was associated with working memory deficits (Duvarci et al., 2018), and D2R overexpression in the striatum led to cognitive deficits (Kellendonk et al., 2006). This evidence concerns the gene DRD2 and Cognitive impairment.