HOTAIR and hepatocellular carcinoma: In HCC, HOTAIR has been demonstrated to be overexpressed and is able to interact and recruit polycomb group complex 2 (PRC2) and lysine specific demethylase 1 (LSD1) complexes to mediate specific gene silencing via histone 3 lysine 27 trimethylation (H3K27me3) repressive marks [55, 56].