TGFβ1 induces the expression of LOXL1 and other extracellular matrix proteins in XFM.21 Based on evidence of epigenetic correlations with XFG, metabolic, physical and environmental conditions would affect the biological functions of XFS-related proteins by changing their expression, secretion, and conformation.22 Despite the effects of oxidative stress and genetic and epigenetic factors on XFS development, the exact pathogenesis of XFS remains unclear. The gene discussed is LOXL1; the disease is exfoliation syndrome.