AGT and hypertensive disorder: The degree of hypertension in the 5/6 nephrectomy animals was mild; however, our findings are consistent with the study by Passos et al. in which induction of significant hypertension in wild-type mice via infusion of angiotensin II and L-NG-nitroarginine methyl ester (systolic 180 mmHg) did not significantly raise microhemorrhage counts [43].