Although the study did not define PARP1’s function, PAR binding to hnRNPs caused the dissociation of hnRNPs from RNA, suggesting a reduction in hnRNP’s noncovalent bonds with PAR by a PARP inhibitor may improve treatments for neurodegenerative diseases [4, 61, 124] (Table 2). Here, PARP1 is linked to neurodegenerative disease.