2016). In parallel, normal cardiac growth was also reduced in Ocx animals. Loss of androgens was associated with a decrease in the basal activation levels of several signaling molecules such as S6 kinase, FAK, and PKD (PKCμ). Physiological heart growth and maladaptive hypertrophy development share and have distinctive signaling pathways. Activation of the Akt/mTOR pathway is associated with pathological CH (even in AR) although normal cardiac growth also relies upon this pathway (Ha et al. 2005; Kemi et al. 2008; Maillet et al. 2013; Volkers et al. 2013; Drolet et al. 2015). This evidence concerns the gene PRKD1 and cyclic hematopoiesis.