NLRP3 and Sepsis: 2016). Only two other studies have shown NLRP3 activation in platelets (Hottz et al. 2013; Murthy et al. 2017). Systemic inhibition of NLRP3 is protective against sepsis‐induced renal and pulmonary injury in mouse models of sepsis and shock (Mao et al. 2013; Luo et al. 2014). NLRP3‐deficient mice showed increased survival which was attributed to decrease autophagy and increased phagocytosis by neutrophils (Jin et al. 2017).