NLRP3 and Sepsis: 2013; Shao et al. 2015). NLRP3 activation is linked to a number of inflammatory conditions, including sepsis (Long et al. 2016); and inhibition of NLRP3 is protective against sepsis‐induced lung injury (Luo et al. 2014) and shock (Mao et al. 2013) in mice. However, very few studies have examined NLRP3 activation in platelets (Hottz et al. 2013; Murthy et al. 2017).