NLRP3 and Sepsis: 2015). NLRP3 activation is linked to a number of inflammatory conditions, including sepsis (Long et al. 2016). Inhibition of NLRP3 is protective against sepsis‐induced organ injury (Luo et al. 2014; Gong et al. 2015; Moon et al. 2015; Wang et al. 2015; Kalbitz et al. 2016) and shock (Mao et al. 2013; Gong et al. 2015). However, there have been only a few studies that have examined NLRP3 activation in platelets (Hottz et al. 2013; Murthy et al. 2017); and none have examined the role of platelet NLRP3 activation in sepsis.