The upregulated expression of ERG and MYCN, which are important transcription factors that are reported to be positively related to poor clinical outcomes in patients with acute myeloid leukaemia and acute lymphocytic leukaemia,40, 47, 48, 49, 50, 51 seemed to induce the LSC accumulation mediated by SETD2 deficiency. The gene discussed is MYCN; the disease is acute myeloid leukemia.