Through analysing the RNA‐seq data, we found no significant alterations of KDM4A, KDM1A and KDM2A in imatinib‐resistant vs imatinib‐sensitive CML cells, indicating that the downregulation of H3K36me3 is mainly caused by SETD2 deficiency rather than histone demethylases. This evidence concerns the gene KDM4A and chronic myelogenous leukemia, BCR-ABL1 positive.