Autosomal familial dominant forms of PD is induced by mutations (A53T, A30P and E46K) (Polymeropoulos et al. 1997; Kruger et al. 1998; Zarranz et al. 2004), or multiplication (duplications, triplications or overexpression) (Chartier-Harlin et al. 2004) in the SNCA gene, probability of sporadic PD also may be increased by polymorphisms at the SNCA locus (Simon-Sanchez et al. 2009). Here, SNCA is linked to Parkinson disease.