ACSL5 is generally decreased in those cancer types where ACSL1 and ACSL4 are upregulated [6], so it would be interesting to deepen our understanding of the mechanisms implicated in this alternative splicing, because it seems that between both isoforms there is a potential response against the two type of cancer cells, the ones that upregulate ACSL5 and the ones that downregulate it. Here, ACSL1 is linked to cancer.