There were some researches revealed that MP-MRI combined PSA or PSAD can improve the ability for PCa detection compared with PSA and PSAD alone15,17,18, but the individualized indexes (such as age, PV) were not included in these researches, and most important is that these studies didn’t add PI-RADS to the predictive model. This evidence concerns the gene KLK3 and posterior cortical atrophy.