This discovery opened the gate for a promising group of drugs for the treatment of T2-DM, SGLT2 inhibitors, and this group includes canagliflozin, which became the first SGLT2 inhibitor approved by the FDA, followed by dapagliflozin, which was approved by the FDA on January 8, 20144,5. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.