RPS6KA3 and neurodegenerative disease: Despite the fact that inhibition of MSK1 and RSK2 leads to the survival of the cells and is an efficient intervention for treatment of several tumors and progressive diseases; however, inhibition of neural cell death is one of the most important mechanisms in order to prevent development of neurodegenerative diseases and also improvement of learning and memory which is directly associated to continuous production of transmitters and maintenance of LTP.