It is important to note, that with a comparable percentage of mainly fibrocellular glomerular crescents (43 ± 3 versus 34 ± 5), patients with pauci immune disease had markedly higher urinary levels of Gremlin than patients with lupus nephritis or IgA nephropathy (298 ug/gCr versus 86 ug/gCr). The gene discussed is GREM1; the disease is lupus nephritis.