The urinary levels of Gremlin were very much lower in other non-crescentic renal diseases (Non CGN n = 66, 72.3 ± 6.8 ug/gCr) and healthy donors (11.3 ± 2.4 ug/gCr) (p < 0.0001) (Fig. 2C). This evidence concerns the gene GREM1 and kidney disorder.