In order to define if these increased Gremlin values were only related to the presence of glomerular crescents, we compared the values in ANCA-crescentic glomerulonephritis with other glomerulopthies (IgA and SLE nephropathy) that presented crescents in more that 25% of the glomeruli. This evidence concerns the gene GREM1 and crescentic glomerulonephritis.