Finally, in order to reject the hypothesis that the difference in urinary Gremlin was only attributed to the number of crescents, we compared patients from both groups, vasculitic and non vasculitic glomerular diseases (15 each group) with a similar number of crescents, observing a strongest amount of urinary Gremlin only in ANCA positive patients (358 ug/gCr vs 102 ug/gCr) (Table 3). This evidence concerns the gene GREM1 and glomerular disorder.