Furthermore, suppression of lnc-TALC or Stat3 in TMZ-resistant GBM cells impaired the enrichment of p300 in the MGMT promoter region (Fig. 6g), the interactivity between p300 and p-Stat3 (Fig. 6h), and the enrichment of H3K9ac, H3K27ac and H3K36ac, but not H3K4ac, in the MGMT promoter region (Fig. 6i and Supplementary Fig. 7e). Here, STAT3 is linked to glioblastoma.