LncARSR is upregulated in hepatocellular carcinoma (HCC), associated with tumor size and advanced stage, which directly binds to PTEN mRNA, promotes PTEN mRNA degradation, regulates PI3K/Akt pathway38, and induces dedifferentiation of cancer stem cells by targeting STAT3 signaling in HCC cells39. This evidence concerns the gene PTEN and hepatocellular carcinoma.