In conclusion, based on the lncRNA microarray, we found that lncRNA lnc-TALC induced by AKT mediated TMZ resistance in GBM, which trapped miR-20b-3p, activated c-Met and increased MGMT expression by remodeling the acetylation of histone H3 in the MGMT promoter regions. The gene discussed is MGMT; the disease is glioblastoma.