We confirmed that the lncRNA MALAT1 had a high expression level in the TMZ-resistant GBM cells (data not shown) and found an unreported lncRNA in GBM, namely, lnc-TALC, that is highly expressed in TMZ-resistant GBM through comparing the expression differences in the lncRNA microarray and the TMZ IC50 after RNAi. Here, MALAT1 is linked to glioblastoma.