GDF5 and osteoarthritis, knee: The osteoarthritis associating variants include the known knee osteoarthritis variant rs143384 in the GDF5 gene32,40 (P = 4.2 × 10−23, OR = 0.91), and the known missense variant in the COL11A1 gene32, rs3753841 (p.Pro1284Leu) that associates with hip osteoarthritis (P = 1.2 × 10−11, OR = 0.92).