Finally, when we correlated TREX2 mRNA expression with the overall survival in the TCGA cancer studies, significant HRs were calculated for laryngeal cancer (HR = 0.726; CL = 0.589–0.895, p = 0.0027; Table 2) and CRC patients (Additional file 1: Table S3). Here, TREX2 is linked to colorectal carcinoma.