DMD and Duchenne muscular dystrophy: More notably, in Duchenne muscular dystrophy compared to healthy controls, alongside expected observations such as downregulation of the dystrophin-associated protein complex and upregulation of extracellular matrix components expected as a result of fibrosis, what may be surprising is the extent to which lysosomal genes were consistently found to be upregulated (Additional file 1: Figure S1F).