Upregulation of the lysosome has not been reported in the literature specifically for dysferlinopathy, although it has been reported as a common feature of muscular dystrophies in a previous gene expression meta-analysis [58], and previous studies of dysferlinopathy have reported dysregulation of specific lumen proteins such as Cathepsin K [59] and Cathepsin S [60]. This evidence concerns the gene CTSS and neuromuscular disease caused by qualitative or quantitative defects of dysferlin.