Previous reports have shown that MSI2 regulates the 3’UTR of HMGA2 in pancreatic adenocarcinoma [42, 43], but based on our results from luciferase reporter assays, the MSI2 promoter region is directly bound by HMGA2, and knockdown or overexpression of MSI2 expression did not affect HMGA2 expression (Fig. 5l and Additional file 1: Figure S1F). Here, HMGA2 is linked to pancreatic adenocarcinoma.