SNHG1 and hepatocellular carcinoma: Nuclear and cytoplasmic fractions possessed 47.5 and 52.5% of total SNHG1, respectively, in untreated Huh7 cells, while sorafenib incubation led to a significant increase of SNHG1 in nuclear fraction (84.7%) (Fig. 1a), indicating that sorafenib may induce a nuclear accumulation of SNHG1 in HCC cells, in support of a previous study where doxorubicin induced SNHG1 nuclear retention [16].