It has been demonstrated that restoring miR-29b expression in MM cells induced anti-proliferative and pro-apoptotic effects, either by targeting mRNAs of CDK6 and MCL-1, usually overexpressed in MM, or mRNA of Sp1, a transcription factor with oncogenic activity in MM [42] and Waldenstrom’s macroglobulinemia [43]. Here, SP1 is linked to Miyoshi myopathy.