MM is commonly preceded by the asymptomatic pre-malignant monoclonal gammopathy of undetermined significance (MGUS), defined by the presence of serum M protein < 30 g/dL, clonal BM PCs infiltration < 10%, with no development of renal insufficiency, anemia, bone lytic lesions, hypercalcemia, or amyloidosis [2]. The gene discussed is MYOM2; the disease is Miyoshi myopathy.