Interestingly, MIR17PTi significantly impaired (i) the pro-survival Myc/miR-17-92 feed-forward loops in patient-derived MM cells, (ii) induced Myc-dependent synthetic lethality, and (iii) inhibited MM growth in both NOD SCID mice bearing subcutaneous MM xenografts and in a SCID-hu model [57]. The gene discussed is MYC; the disease is Miyoshi myopathy.