CDH2 and head and neck squamous cell carcinoma: Beside N-cadherin, some other intermediate filament proteins and ECM-associated proteins such as alpha-smooth muscle actin (α-SMA), vimentin and laminin 5 are highly expressed in HNSCC compared to normal tissue, and are associated with an invasive phenotype and therapy resistance, whereas their expression levels correlate with poor prognosis [132,133].