In an experiment with PON-2 (−/−) mice, in order to evaluate the relationship between PON-2 and coagulation, Ebert et al., [148], observed an increase in oxidative stress, endothelial dysfunction and the concentration of interleukin-6 in the vasculature, as well as increased tissue factor activity in endothelial cells, in vitro. This evidence concerns the gene PON2 and endothelial dysfunction.