In vitro studies have shown that the expression of the PON-2 protein regulates the Wnt/GSK3β/β-catenin pathway in multiple cell lines (K562, SCC-4, PCI-13); besides, a correlation between PON2 and β-catenin expression was observed in ex-vivo tumor tissue of oral squamous cell cancer (OSCC). The gene discussed is PON2; the disease is neoplasm.