Higher activation of p53, p63, p73, activator protein 1 (AP-1), MYC, hypoxia-inducible factor 1-alpha (HIF1A), fibroblast growth factor receptor 3 (FGFR3), and MAPK pathways were found to be distinguishing features of squamous cell carcinomas, while adenocarcinomas exhibited higher inferred activation of estrogen receptor alpha (ERα), forkhead box protein A1 (FOXA1), FOXA2, and FGFR1 signaling [9]. Here, ESR1 is linked to adenocarcinoma.