Higher activation of p53, p63, p73, activator protein 1 (AP-1), MYC, hypoxia-inducible factor 1-alpha (HIF1A), fibroblast growth factor receptor 3 (FGFR3), and MAPK pathways were found to be distinguishing features of squamous cell carcinomas, while adenocarcinomas exhibited higher inferred activation of estrogen receptor alpha (ERα), forkhead box protein A1 (FOXA1), FOXA2, and FGFR1 signaling [9]. The gene discussed is HIF1A; the disease is squamous cell carcinoma.