Cancer cells adapt and survival to various forms of oxidative, electrophilic, thermal and inflammatory stress by activating not only the HSF/HSP response and UPR but also the nuclear factor erythroid 2-related factor 2 (NRF2) encoded by the NFE2L2 gene, considered the major regulator of the antioxidant response [71]. The gene discussed is HSP90B2P; the disease is cancer.