NFE2L2 and cancer: Given their proliferative nature due to oncogene activation, cancer cells undergo various forms of intrinsic stress and adverse environmental challenges, such as oxidative, electrophilic, proteotoxic, inflammatory stress, and nutrient deprivation, that try to manage by activating molecular/cellular pathways, such as autophagy, heat shock protein (HSP), antioxidant response by nuclear factor erythroid 2-related factor 2 (NRF2), endoplasmic reticulum (ER) stress, and unfolded protein response (UPR), pathways often interconnected.