Intriguingly, several mutp53 proteins (i.e., R273H, R175H, R280K) induce HSF1 upregulation, and mutp53R280K has been shown to interact with activated p-Ser326 HSF1 stimulating its transcriptional activity toward HSP90 and HSP70, in breast cancer cells [30]. The gene discussed is HSF1; the disease is breast carcinoma.