Intriguingly, IRE1α is overexpressed in cancer cells lines expressing mutp53, compared to cells expressing wild-type p53, linking mutp53 to the adaptation of tumor cells to ER stress and highlighting an important proof-of-concept for targeting UPR, particularly the IRE1/XBP1 pathway, in tumors harboring mutant p53 [62]. The gene discussed is ERN1; the disease is neoplasm.