The best described mechanism of mutp53 GOF is its ability to interact with other transcription factors including NF-Y, Sp1, ETS1/2, NF-kB and SMADs [12], and this interaction profoundly changes the cancer cell transcriptome and proteome, supporting cancer cell survival, tumor progression, invasion, metastasis and chemoresistance [13,14,15]. The gene discussed is NFKB1; the disease is cancer.