Although the example is performed with a cardiomyocyte model, the framework and the workflow is analogous for different models describing a biological experiment and may thus be interesting for the application in other diseases where the Ras/Raf/MEK/ERK1/2 cascade is involved in such as cancer, Parkinson, Rasophathies [11,27,28]. The gene discussed is MAPK3; the disease is Parkinsonism.