By gene dosage using real-time quantitative, Boulay and colleagues documented Smad7 deletion in 43% (77/178) of CRC biopsy samples and showed that patients with tumors in which deletions of Smad7 had been documented, had a low hazard ratio for death and relapse [86], clearly defining Smad7 as a negative prognostic marker in patients with CRC. Here, SMAD7 is linked to colorectal carcinoma.