More recently, data from 205 skin melanoma primary tumors showed that Smad7 was expressed in almost all the specimens, with a predominantly nuclear pattern, and high Smad7 expression was positively associated with several features of tumor aggressiveness (i.e., presence of ulceration, higher tumor thickness, higher mitotic rate) and independently predicted an unfavorable prognosis [80]. This evidence concerns the gene SMAD7 and cutaneous melanoma.