A recent work from Wang and co-workers reported some different results and showed that Nuclear reporter subfamily 2, group F, and member 2 (NR2F2), a pleiotropic mediator involved in several physiological processes and up-regulated in CRC cells, induced a TGFβ1-dependent EMT through Smad7 inhibition. The gene discussed is SMAD7; the disease is colorectal carcinoma.