AMOT and cancer: Since LATS is the major regulator of YAP/TAZ and AMOT and its interaction with Hippo signaling pathway can also regulate cell shape and motility of non-endothelial cells, which play important roles in cancer biology [62], how the LATS–AMOT interaction can affect YAP/TAZ function in angiogenesis is a critical question for future studies (Figure 3).