CASP3 and neoplasm: In another study, formononetin at doses of 25, 50 or 100 mg/kg administered for 14 days significantly suppressed the growth of subcutaneously implanted osteogenic sarcoma U2OS tumor growth and was associated with the downregulation of miR-375 with concomitant upregulation of Bax, Caspase-3, and Apaf-1 [114].