The inhibition of angiogenesis in xenografted human breast cancer (MDA-MB-231) by formononetin was found to modulate FGF2-induced micro-vessel growth that suppressed the emergence of rat aortic rings and angiogenesis through the repression of FGF2-initiated activation of FGFR2 and AKT signaling [121]. This evidence concerns the gene AKT1 and breast cancer.