CDK4 and Familial prostate cancer: Similarly, formononetin induced G1 arrest in PC-3 and DU-145 prostate cancer cells by downregulating cyclin D1, protein kinase B (AKT), and cyclin dependent kinase 4 (CDK4) in a concentration-dependent manner, and this phenomenon was observed to be more significant in PC-3 cells than DU-145 cells [95].