VEGFA and colorectal adenocarcinoma: In one study, formononetin downregulated the expression of key pro-angiogenic factors, such as vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs), in LoVo human colorectal adenocarcinoma cells and reduced xenografted tumor size and the number of proliferating cells in the tumor tissues with decreased serum VEGF level [109].