TNF and inflammatory bowel disease: A meta-analysis of 15 studies (including one Japanese study as an Asian study) investigated the association between anti-TNF therapy and polymorphism to identify genetic biomarkers related to anti-TNF therapy in patients with IBD, five different genotypes (TLR2 rs4696480 TT, TLR2 rs11938228 AC, IL6 rs10499563 TT, IL12B rs3212227 AC, IL12B rs3212217 CG) were significantly correlated with a non-response to anti-TNF in UC [140,141].