INSIG1 and colorectal carcinoma: Other proteins related to FA biosynthesis and lipid metabolism regulation, such as acetyl-CoA carboxylase (ACC), Insulin induced gene 1 (INSIG1), and sterol regulatory element-binding protein 1 (SREBP1), are highly expressed in breast cancer tumors and associated with low patient survival [147] while colorectal carcinoma risk has been associated with hepatic lipase polymorphisms [148].